Multicentric Adenocarcinomas in a Long-Segment of Barrett’s Esophagus

نویسندگان

  • Stefan Hartl
  • Joerg-Ruediger Siewert
  • Joerg Theisen
چکیده

This report describes a complicated course of a 58-year-old patient with multicentric Barrett's carcinoma within a long-segment of Barrett metaplasia. After abdominal-thoracic resection of the cancer, with incomplete removal of the long-segment metaplastic lesion, invasive carcinoma was diagnosed in the remnant Barrett's segment. Endoscopic mucosal resection was done, but Barrett's mucosa was left in situ again. Recurrent tumor growth was diagnosed only few months later. Finally, transthoracic complete resection on the remnant Barrett's segment was performed. Thus, our case demonstrates impressively the appearance of multicentric adenocarcinomas in Barrett's esophagus and underlines the necessity of resection of the complete Barrett mucosa.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

BARRETT’S ESOPHAGUS AND ASSOCIATED ADENOCARCINOMA - Studies on pathogenesis, clinical staging, and cost-utility of cancer treatment

.................................................................................................................... 8 INTRODUCTION ......................................................................................................... 10 REVIEW OF THE LITERATURE ................................................................................. 12 1. Barrett’s esophagus ..........................

متن کامل

Barrett’s Esophagus - American Family Physician

managed in the primary care setting. Surveys suggest that approximately 20 percent of U.S. adults have symptoms of GERD at least once a week.4 A subgroup of patients with GERD develop severe complications that include erosive esophagitis, stricture formation, Barrett’s esophagus, and adenocarcinoma of the esophagus. Because Barrett’s esophagus is thought to be associated with the development of...

متن کامل

Metabolism Functional Modules Related to Inflammation and Lipid of Esophagus and Stomach: Differential Activity of Expression Profile of Malignant and Nonmalignant Lesions

Adenocarcinomas of stomach and esophagus are frequently associated with preceding inflammatory alterations of the normal mucosa. Whereas intestinal metaplasia of the gastric mucosa is associated with higher risk of malignization, Barrett’s disease is a risk factor for adenocarcinoma of the esophagus. Barrett’s disease is characterized by the substitution of the squamous mucosa of the esophagus ...

متن کامل

Undergo Clonal Expansion in Barrett's Metaplastic Epithelium Lesions Are Common, Early Abnormalities

Barrett’s esophagus (BE) is the only known precursor to esophageal adenocarcinoma, a cancer of which the incidence has been increasing at an alarming rate in Western countries. p16 lesions occur frequently in esophageal adenocarcinomas but their role in neoplastic progression is not well understood. We detected 9p21 loss of heterozygosity, p16 CpG island methylation, and p16 mutations in biopsi...

متن کامل

Barrett’s Esophagus Definition and Complications

Barrett’s esophagus (BE) is defined as columnar metaplasia of esophageal squamous epithelium, of any length, that can be recognized at endoscopy, and is confirmed to have intestinal metaplasia (goblet cells) by mucosal biopsy analysis of the tubular esophagus (1). By definition, this disease does not include intestinal metaplasia of the cardia. Thus, the current definition of BE includes indivi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2008